Predicted functional alterations in colonic microbiota metabolism underlie ethanol consumption and preference behavior in mice.

ABSTRACT:

Background

Alcohol use disorder (AUD) is a complex condition affecting several body systems. Gut microbiota alterations, intestinal-barrier disruption, and the consequent translocation of metabolites foster chronic inflammation, lower short-chain fatty acid (SCFA) output, and depleted beneficial bacteria may contribute to transcriptional, epigenetic, and metabolic changes that influence ethanol preference.

Methods

Two experimental phases were used. T1 (8 weeks): mice received either the American Institute of Nutrition standard diet (AING) or a high-sugar-butter (HSB) diet. T2 (4 weeks): HSB animals switched to AING (SWITCH), while AING mice maintained the same diet. Each diet arm was split into ethanol (EtOH; free access to 10% ethanol) or H₂O, generating four gro

SUBMITTER: Velten Mendes M 

PROVIDER: S-EPMC12638287 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature