Mediation and moderation by inflammation and dietary patterns in heavy metal exposure effects on kidney function.

ABSTRACT: Heavy metals are highly nephrotoxic and may increase the risk of chronic kidney disease. However, the potential roles of inflammatory responses and dietary patterns in the relationship between heavy metals and kidney disease remain underexplored. This study examines the heavy metal exposure-inflammatory response-kidney function decline pathway and the modulating role of dietary patterns in heavy metal-induced kidney damage. Results from generalized linear models, restricted cubic spline models, and weighted quantile regression models show that exposure to individual heavy metals in blood and urine (except urinary mercury) is associated with a decrease in estimated glomerular filtration rate (eGFR) and an increase in urine albumin/creatinine ratio (UACR) and Systemic Inflammatory Response I

SUBMITTER: Zhong Z 

PROVIDER: S-EPMC12638307 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature