Altered systemic bioenergetic reserve in chronic kidney disease predisposes hearts to worse functional outcomes.

ABSTRACT: Chronic kidney disease (CKD) is characterised by progressive loss of kidney function and structural damage, which contributes to systemic complications, including cardiovascular dysfunction. Inter-organ metabolic interactions are increasingly recognised as important in the pathophysiology of CKD, but the extent to which systemic bioenergetic deficits contribute to cardiac dysfunction remains unclear. We investigated cardiac and systemic metabolic remodeling in two rat models of CKD with distinct aetiologies: glomerulosclerosis induced by partial nephrectomy and interstitial fibrosis induced by an adenine-rich diet. Despite differing renal pathology, both models exhibited comparable cardiac dysfunction, including impaired recovery following 25 min of ischaemia. ¹H NMR spectroscop

SUBMITTER: Young M 

PROVIDER: S-EPMC12638317 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature