Secretory phospholipase A₂-IIA targets bacterial extracellular vesicles to modulate immune signaling.

ABSTRACT: Secretory phospholipase A₂-IIA (sPLA₂-IIA) is a bactericidal enzyme that hydrolyzes membrane phospholipids, releasing lipid metabolites that can affect inflammation. sPLA₂-IIA exhibits poor activity toward eukaryotic cells but preferentially targets gram-positive bacterial membranes. While sPLA₂-IIA is constitutively expressed in the intestine and upregulated by inflammation in various bodily fluids, its precise physiological substrates remain debated. Intriguingly, sPLA₂-IIA can modulate the intestinal lipidome without altering the microbiota composition. Here, we investigated whether sPLA₂-IIA could use membranes from bacterial extracellular vesicles (bEVs) as alternative substrates to modulate immune signaling. We found t

SUBMITTER: Dore E 

PROVIDER: S-EPMC12638318 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature