White matter brain age as a biomarker of cerebrovascular burden in the ageing brain.

ABSTRACT: As the brain ages, it almost invariably accumulates vascular pathology, which differentially affects the cerebral white matter. A rich body of research has investigated the link between vascular risk factors and the brain. One of the less studied questions is that among various modifiable vascular risk factors, which is the most debilitating one for white matter health? A white matter specific brain age was developed to evaluate the overall white matter health from diffusion weighted imaging, using a three-dimensional convolutional neural network deep learning model in both cross-sectional UK biobank participants (n = 37,327) and a longitudinal subset (n = 1409). White matter brain age gap (WMBAG) was the difference between the white matter age and the chronological age. Participants with

SUBMITTER: Du J 

PROVIDER: S-EPMC12638326 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature