Diffusion-weighted magnetic resonance spectroscopy with selective refocusing.

ABSTRACT:

Objective

To reduce errors from J-modulations and spectral overlap in dMRS of brain metabolites, this study combines the use of diffusion-weighted gradients with selective refocusing and spectral editing.

Materials and methods

Bipolar gradients were combined with spectral refocusing and editing in a dMEGA-PRESS sequence. Experimental parameters were optimised for spectral editing of GABA, with co-editing of Glutamate and Glutamine. The method was tested in metabolite phantom solutions, followed by pre-clinical experiments on rats.

Results

The dMEGA-PRESS sequence enabled reliable spectral editing and quantification of GABA. Selective refocusing and editing resulted in reduced uncertainty in the diffusion data for GABA and Glutamate in the metabolite phantoms, and also

SUBMITTER: Berg E 

PROVIDER: S-EPMC12638348 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature