A dedicated phantom for exploring the interplay of fat and paramagnetic substances in quantitative susceptibility mapping.

ABSTRACT:

Objective

Accurate quantitative tissue characterization in organs with considerable fat content, like the liver, requires thorough understanding of fat's influence on the MR signal. To continue the investigations into the use of quantitative susceptibility mapping (QSM) in abdominal regions, we present a dedicated phantom that replicates liver-like conditions in terms of effective transverse relaxation rates (R₂*) and proton density fat fractions.

Materials and methods

The spherical agar phantom consists of nine smaller spheres (diameter: 3 cm) doped with a paramagnetic substance (iron nanoparticles or manganese chloride) and fat (peanut oil), embedded in a large agar sphere (diameter: 14 cm), ensuring no barriers exist between the enclosed spheres and their surro

SUBMITTER: Graf S 

PROVIDER: S-EPMC12638357 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature