In-vivo liver proton density fat fraction quantification at 0.55 T: a pilot study with comparison against 3 T MRI.

ABSTRACT:

Background

Proton density fat fraction (PDFF)- the ratio of unconfounded fat signal to the sum of the unconfounded fat and water signals, is a valuable quantitative imaging biomarker of metabolic associated steatotic liver disease (MASLD) widely applied in clinical practice and clinical trials. PDFF of the liver is commonly measured using 3 T MRI systems. However, low-field systems are increasingly favored due to lower cost, improved safety profile, minimized artifacts around metallic implants, and enhanced patient comfort.

Objective

In this pilot study, we used knowledge of standardized and widely used 3 T liver PDFF protocols, and adapted parameters to be appropriate for the 0.55 T MRI. We evaluate a liver fat quantification protocol at 0.55 T compared to a standard clinic

SUBMITTER: Wong RE 

PROVIDER: S-EPMC12638424 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature