Vitamin D3 Improves Hypothalamic-Pituitary-Adrenal Axis Function, Immunological Responses, and Gut Dysbiosis in Sleep Desynchrony.

ABSTRACT:

Purpose

Chronic sleep desynchrony proliferates in modern society, characterized by extended wakefulness and disrupted circadian rhythms over a long period, and is associated with various physiological and immune dysfunctions. This study investigated the health effects of long-term sleep desynchrony and subsequent vitamin D3 treatment, alongside sleep recovery, on biological factors in C57BL/6J mice by assessing their body weight, metabolic activity, stress response, immune function, and gut microbiota composition.

Methods

Mice underwent 28 days of sleep desynchrony using a Lafayette chamber to model chronic disruption of the HPA axis, immune function, and gut microbiota.

Finding

Sleep desynchrony did not significantly alter body weight, food intake, or water consumpti

SUBMITTER: Wu CW 

PROVIDER: S-EPMC12638446 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature