Development and validation of nomograms for distant metastasis and prognosis of small intestinal neuroendocrine tumors.

ABSTRACT:

Background

Small intestinal neuroendocrine tumors (SI-NETs) are difficult to diagnose early and are associated with a poor prognosis due to distant metastasis (DM). This study aims to develop and validate two prediction models to predict risk of DM and prognosis of SI-NETs patients with DM.

Methods

This study included patients diagnosed with SI-NETs from the Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2021. Univariate and multivariate logistic regression analyses were used to identify independent risk factors for DM. A nomogram was developed using these factors to predict the risk of DM. Separately, for prognostic modeling, patients with DM were selected. Candidate prognostic variables were first screened using the least absolute shrinkage an

SUBMITTER: Xu C 

PROVIDER: S-EPMC12638566 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature