Cardiovascular risk factors and the allostatic interoceptive network in dementia.

ABSTRACT:

Aims

Cardiovascular risk factors, such diabetes, hypertension, blood pressure, obesity, and smoking, are linked with allostatic-interoception-the continuous monitoring of internal bodily states in anticipation of environmental demands. These risk factors are associated with dementia risk. How these factors affect brain networks vulnerable to neurodegeneration and involved in allostatic-interoception, such as the Allostatic-Interoceptive Network (AIN), is unknown. We investigated the relationship between cardiovascular risk and AIN structure and function in frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD).

Methods and results

We recruited 1501 participants (304 with FTLD, 512 with AD, and 685 healthy controls) from the Multi-Partner Consortium to Expand D

SUBMITTER: Hazelton JL 

PROVIDER: S-EPMC12638725 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature