Invasive validation of novel 1D models for computation of coronary fractional flow reserve.

ABSTRACT:

Aims

Computed virtual fractional flow reserve (vFFR), derived from invasive angiography, non-invasively quantifies coronary epicardial lesion physiology. Developments of 1-dimensional (1D) vFFR models have introduced methods of side-branch flow representation and reduced simulation time by several orders of magnitude vs. 3-dimensional (3D) alternatives. This study aimed to quantify agreement and diagnostic accuracy of 1D and 3D vFFR models, in a matched cohort, and compare results with established FFR alternatives.

Methods and results

We used five 1D models, which differed in their side-branch flow representation, to compute vFFR in 104 arteries. The simplest model ignored side-branch flow, the second and third models used vessel anatomy to homogenously distribute side-branc

SUBMITTER: Taylor DJ 

PROVIDER: S-EPMC12638729 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature