Multi-attribute monitoring (MAM) methodology for glycosylated subunit vaccines.

ABSTRACT: Many protein-based vaccines comprise viral surface proteins which are chosen for their ability to stimulate the immune system. These vaccine molecules are often heavily glycosylated, and glycosylation plays critical roles in the immunological and stability properties of vaccines. The structural characterization and product quality attribute monitoring of such complex vaccine therapeutics during process development and manufacturing is very challenging. High throughput monitoring of multiple molecular attributes, particularly glycosylation, of recombinant glycoprotein subunit vaccines are needed to support entire vaccine production processes. Multi-attribute monitoring (MAM) technology involves assessing multiple critical molecular attributes of molecules in one set of analyses in an automa

SUBMITTER: Shajahan A 

PROVIDER: S-EPMC12638818 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature