The effects of polygenic risks for alcohol misuse on negative emotion processing in young adult binge drinkers.

ABSTRACT: Extensive research has documented altered emotion processing in binge drinkers. Genetic risks contribute to problem drinking; however, it remains unclear how genetic risks for alcohol misuse affect behavioral and brain responses to negative emotions. We curated data from the Human Connectome Project and identified 97 binge (69 men) and 379 demographically-matched non-binge (142 men) drinkers performing an emotion task during brain imaging. Alcohol use severity was quantified by the first principal component (PC1) identified of principal component analysis of 15 drinking measures. Polygenic risk scores (PRS) for alcohol dependence were computed for all subjects. With published routines and at a corrected threshold, we evaluated how brain responses to matching negative emotional faces vs. ge

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12638819 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature