Exploring the potential mechanisms of anti-pulmonary fibrosis effects of Luo Han Guo via network pharmacology, molecular docking, and experimental validation.

ABSTRACT: Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung condition distinguished by a complex etiology, poor prognosis and exhibiting high mortality rates. While therapeutic drugs are currently available, they often come with notable side effects. Luo Han Guo (LHG), a medicinal plant, is known for its properties in moistening the lungs, relieving cough, calming asthma, and resolving phlegm; however, systematic research on its potential therapeutic mechanisms and active ingredients for IPF is lacking. This study utilized network pharmacology to predict the active ingredients, key targets, and potential mechanisms of LHG's anti-IPF effects, followed by molecular docking simulations of the active ingredients and their potential targets, which were subsequently validated through in v

SUBMITTER: Cui Q 

PROVIDER: S-EPMC12638836 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature