Amniotic membrane transplantation promotes retinal hole closure in a rabbit model.

ABSTRACT: Amniotic membrane transplantation (AMT) is an effective treatment for refractory macular hole closure, yet the underlying mechanism supporting that effectiveness remains unclear. Here, we investigated the role of retinal regeneration in this process using an in vivo rabbit retinal-hole (RH) model in which AMT was performed on one of the holes. Histological and immunofluorescence examinations with anti-glial fibrillary acidic protein and anti-glutemine synthetase antibodies were conducted to evaluate cell migration and hole closure. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were used to analyze the tissues after implantation. Optical coherence tomography scans revealed that AMT promoted RH closure. Histological analyses demonstrated that retinal pigment e

SUBMITTER: Tanaka H 

PROVIDER: S-EPMC12638848 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature