Preparation and evaluation of Dendrobium formosum extract-loaded microemulsions for anti-aging purpose.

ABSTRACT: Skin aging is a complex process caused by oxidative stress, leading to a growing need for cosmeceuticals with effective antioxidant and matrix metalloproteinase-1 (MMP-1) inhibitory activities. D. formosum has shown various biological activities; however, an appropriate delivery system is required to enhance its efficacy. Our study firstly explored the protective effects of D. formosum extract on UVB-irradiated human keratinocytes (HaCaT) and human fibroblasts (BJ), and then developed topical microemulsion (ME) containing D. formosum extract. Our results show that D. formosum extract demonstrates anti-aging properties by reducing intracellular reactive oxygen species (ROS) in UVB-irradiated HaCaT and BJ, and inhibiting MMP-1 expression. Pseudo-ternary phase diagrams were constructed using

SUBMITTER: Thungmungmee S 

PROVIDER: S-EPMC12638850 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature