RNF115 upregulation by YBX1-dependent m5C modification promotes hepatocellular carcinoma progression.

ABSTRACT: 5-methylcytosine (m5C) RNA modification plays critical roles in post-transcriptional regulation and cancer progression. However, the downstream effectors of the m5C reader protein YBX1 and their mechanistic contribution to hepatocellular carcinoma (HCC) remain largely undefined. In this study, we performed transcriptome-wide m5C profiling and observed significant heterogeneity in m5C modification patterns in HCC, with differentially methylated genes broadly distributed across the genome except for chromosome Y. We found that YBX1 is markedly upregulated in HCC and significantly correlated with poor patient prognosis. Functionally, YBX1 promoted tumor cell proliferation, migration, and invasion in vitro and in vivo. By integrating m5C MeRIP-seq and YBX1 RIP-seq data, we identified RNF115 as

SUBMITTER: Li J 

PROVIDER: S-EPMC12638859 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature