MAGEA11 promotes GC proliferation, migration, and invasion through activation of E2F1 transcriptional activity.

ABSTRACT: Gastric cancer (GC) is a prevalent gastrointestinal malignancy in China. Despite advancements in multidisciplinary diagnosis and treatment strategies, the 5-year survival rate remains low at just 10-20%. A significant number of patients ultimately die from postoperative recurrence and distant metastasis. Therefore, it is crucial to investigate the core mechanisms underlying GC development and progression and to identify potential molecular targets for early diagnosis, prevention, and treatment. MAGEA11, part of the melanoma-associated antigen (MAGE) gene family, is associated with several cancers. However, its expression, function, and mechanisms in GC remain unclear. In this study, we first confirmed that MAGEA11 is highly expressed in GC through data analysis from The Cancer Genome Atlas

SUBMITTER: Shen Q 

PROVIDER: S-EPMC12638882 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature