Inhibition of FKBP5 alleviates obstetric antiphospholipid syndrome by regulating macrophage polarization.

ABSTRACT: Immune homeostasis disturbance within the placental microenvironment plays a key role in the pathogenesis of obstetric antiphospholipid syndrome (OAPS), although the underlying mechanisms remain poorly understood. This study aimed to investigate the immune regulatory role of FK506-binding protein 5 (FKBP5) in OAPS-associated pathological pregnancies. RNA sequencing and immunocytotyping were performed on decidual tissues from OAPS patients and healthy controls. Bone marrow-derived macrophages (BMDMs) polarization assays and macrophage‒trophoblast coculture models were employed to explore the effects and mechanisms of FKBP5 on macrophage polarization at the maternal-fetal interface. We applied an animal model of OAPS and comprehensively evaluated the therapeutic effects of the FKBP5 inhibito

SUBMITTER: Song M 

PROVIDER: S-EPMC12638907 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature