Multimorbidity, disease clusters and risk of all-cause and cause-specific mortality: a population-based prospective cohort study.

ABSTRACT: The number of people living with ≥ two health conditions, termed multimorbidity, is increasing. We investigated the impact of multimorbidity on all-cause and cause-specific mortality risk in 502,370 UK Biobank participants aged 40 to 70 years. Participants attended an assessment centre between 2006 and 2010 and self-reported medical conditions during a nurse-led verbal interview. The presence of ≥ 2 long-term conditions from a preselected list of 43 conditions was used to define multimorbidity. In a training sample (80% of participants with multimorbidity), disease clusters were identified in four groups: women aged (1) 40-59 or (2) 60-70, and men aged (3) 40-59 or (4) 60-70. Mortality was ascertained from linkage to death records. Multivariate Cox proportional-hazards regression models we

SUBMITTER: Littlejohns TJ 

PROVIDER: S-EPMC12638925 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature