Serum Proteomics Reveals Diagnostic Biomarkers and Molecular Pathways in Cerebral Palsy.

ABSTRACT: Cerebral palsy (CP), a prevalent non-progressive neurological disorder in children, lacks reliable biomarkers for early diagnosis, and its molecular mechanisms remain poorly understood. In this study, we conducted serum proteomic profiling of 346 CP patients and 190 healthy controls and developed a 10-protein multi-marker panel for application in diagnosis of CP. The panel was further validated in an independent CP cohort using an orthogonal method, enzyme-linked immunosorbent assay (ELISA). By integrating serum proteomic data with whole-exome sequencing (WES) results, we found that CP patients carrying pathogenic variants exhibited downregulation of synaptic and calcium signaling pathways at the protein level. We also explored the impact of clinical risk factors on the proteome, identifyi

SUBMITTER: Xu Y 

PROVIDER: S-EPMC12638935 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature