Effect of polygenic scores on the relationship between psychosis and cognition.

ABSTRACT: Cognitive impairment is an important but often under-researched symptom in psychosis. Both psychosis and cognition are highly heritable and there is evidence of a genetic effect on the relationship between them. Using samples of adults (N = 4 506) and children (N = 10 981), we investigated the effect of schizophrenia and bipolar disorder polygenic scores on cognitive performance, and intelligence and educational attainment polygenic scores on psychosis presentation. Schizophrenia polygenic score was negatively associated with visuospatial processing in adults (beta: -0.0569; 95% confidence interval [CI]: -0.0926, -0.0212) and working memory (beta: -0.0432; 95% CI: -0.0697, -0.0168), processing speed (beta: -0.0491; 95% CI: -0.0760, -0.0223), episodic memory (betas: -0.0581 to -0.0430; 95%

SUBMITTER: Varney L 

PROVIDER: S-EPMC12638944 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature