Increased basal ganglia volume in older adults with tinnitus.

ABSTRACT: Tinnitus is the perception of sounds without external stimuli, affecting 10%-15% of the general population and up to 25% of individuals over 70 years of age. While traditionally viewed as an auditory phenomenon, growing evidence highlights the role of the central nervous system in its pathophysiology. One of the proposed mechanisms, the "gating hypothesis" of tinnitus, suggests an alteration in the modulation of sensory activity by the frontostriatal network. Although structural changes in frontal areas support this idea, gray matter differences in subcortical regions-such as the auditory pathway and basal ganglia-remain poorly understood. Here, we examined subcortical structures and auditory function in older adults with mild presbycusis from the ANDES cohort, including 51 tinnitus patien

SUBMITTER: San-Martin S 

PROVIDER: S-EPMC12638945 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature