Methylphenidate stabilizes dynamic brain network organization during tasks probing attention and reward processing in stimulant-naive children with ADHD.

ABSTRACT: Children with ADHD often exhibit fluctuations in attention and heightened reward sensitivity. Psychostimulants, such as methylphenidate (MPH), improve these behaviors in many, but not all, children with ADHD. Given the extent to which psychostimulants are prescribed for children, coupled with variable efficacy on an individual level, a better understanding of the mechanisms through which MPH changes brain function and behavior is necessary. MPH's primary action is on catecholamines, including dopamine and norepinephrine. Catecholaminergic signaling can influence the tradeoff between flexibility and stability of brain function, which is one candidate mechanism through which MPH may alter brain function and behavior. Time-varying functional connectivity, which models how functional brain net

SUBMITTER: Nugiel T 

PROVIDER: S-EPMC12638959 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature