MiRNome alterations drive the malignant transformation of endometriosis into endometriosis-correlated ovarian cancer.

ABSTRACT: Endometriosis (EMS) is a chronic gynecological condition affecting 6-10% of reproductive-age women. These lesions, albeit of benign nature, present cancer-like features, and may progress to epithelial ovarian cancer (EOC) through a multistep process. The coexistence of EMS and EOC in the presence of transitional lesions (TL) - i.e. atypical EMS/borderline lesions - is termed as endometriosis-correlated ovarian cancer (ECOC). Given the regulatory role of miRNAs in gene expression and biological pathways, we aimed to identify miRNAs that may drive or modulate the malignant transformation of ovarian EMS. Global miRNA profiling was evaluated on 81 samples (EMS, TL and ECOC) from 44 patients. Principal component analysis and unsupervised clustering revealed two distinct clusters formed by ECOC

SUBMITTER: Coada CA 

PROVIDER: S-EPMC12638967 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature