Sustainable repeated-batch fermentation of immobilized Ganoderma formosanum for enhanced production of anti-melanogenic bioactive compounds.

ABSTRACT: Ganoderma formosanum, an edible medicinal fungus renowned for its bioactive metabolites, faces challenges in traditional cultivation due to prolonged timelines and elevated costs, hindering its integration into functional food formulations. This study introduces an innovative, sustainable fermentation platform by immobilizing G. formosanum mycelia (GFM) on plastic composite support (PCS) within an airlift bioreactor, utilizing agricultural byproducts to foster eco-efficient production of natural anti-melanogenesis compounds with potential as functional food ingredients. Initial shake-flask evaluations identified the SY-PCS matrix, comprising soybean hulls, polypropylene, and yeast extract, as optimal for mycelial immobilization, yielding anti-melanin activity equivalent to 79.78% of kojic

SUBMITTER: Hsieh CC 

PROVIDER: S-EPMC12638983 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature