Bedtime snacking and glycemic deterioration in young children with Type 1 diabetes on multiple daily injections: a randomized controlled crossover trial.

ABSTRACT:

Objective

To determine if a bedtime snack in young children with type 1 diabetes (T1D) prevents nocturnal hypoglycemia, and the impact on glycemia overnight.

Methods

In this randomized controlled crossover trial, 10 grams of carbohydrate (milk, yoghurt, and kefir) was given 150-180 minutes after dinner over three nights to 5-8-year-old children with T1D using multiple daily injection therapy. Continuous glucose monitoring (CGM) data were collected for 6 hours following the snacks on one control and three snack nights. Time in 70-180 mg/dL (3.9-10 mmol/L) range (TIR), time below 70 mg/dL (3.9 mmol/L) (TBR), and other metrics were analyzed according to international CGM consensus. Trial day was terminated if blood glucose exceeded 300 mg/dL (16.7 mmol/L) or fell below 70 mg/dL

SUBMITTER: Gokce T 

PROVIDER: S-EPMC12639072 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature