Integrative profiling strategies to guide personalized therapy in mantle cell lymphoma: a pilot study.

ABSTRACT: Mantle cell lymphoma (MCL) responds to frontline therapy but is susceptible to relapse. While Bruton's tyrosine kinase inhibitors (BTKi) achieve high response rates, most patients eventually experience disease progression. Predicting responses to subsequent treatments remains challenging due to the lack of an established platform. Heterogeneity in gene alterations and cellular pathways contribute to resistance, complicating treatment approaches. Here, we present a multi-modal profiling platform, targeting key pathways rather than focusing on singular DNA-associated lesions. We identified dysregulated signaling pathways by performing gene expression profiling on 20 MCL samples using a custom MCL MATCH gene set and analyzed the data with gene-set variation analysis. We also screened 22 thera

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12639073 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature