2-[¹⁸F]FDG PET identifies metabolic substrates of sudden cardiac death in hypertrophic cardiomyopathy.

ABSTRACT: Risk stratification for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) remains challenging. Enhanced imaging techniques could improve prognostic accuracy. This study investigates myocardial resting perfusion and metabolism using [¹³N]-NH₃ and 2-[¹⁸F]FDG PET/CT and their correlation with HCM SCD risk scores. Thirty non-obstructive HCM patients (mean age 54 years, 57% male) with a mean SCD risk score of 3.7 ± 2.5% were evaluated. Myocardial 2-[¹⁸F]FDG metabolism and rest [¹³N]-NH₃ perfusion PET/CT were analyzed. Hypermetabolism (2-[¹⁸F]FDG uptake with normal perfusion) occurred in 53% of cases (mean extension 11.8 ± 17.2%), while fibrosis (reduced perfusion without 2-[¹⁸F]FDG uptake) aver

SUBMITTER: Marques-Alves P 

PROVIDER: S-EPMC12639081 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature