Associations between TNF gene promoter variants (rs361525, rs1800629, rs1799964, rs1799724) and the clinical course of idiopathic inflammatory myopathies.

ABSTRACT: Idiopathic inflammatory myopathies (IIM) are characterized by muscle weakness and immune-mediated muscle injury. Tumor necrosis factor (TNF) appears to be involved in the pathogenesis of IIM, especially regarding susceptibility to malignancy. Here, we analyzed associations between variants of the TNF gene promoter and the clinical course of the disease. We conducted a case-control study that analyzed selected variants of the TNF gene promoter (rs361525, rs1800629, rs1799964, rs1799724) in 56 stable IIM patients using commercially available TaqMan allelic discrimination assays with real-time PCR. Clinical and laboratory data were collected to evaluate associations between genotypes and disease manifestations. Control subjects (n = 38) matched for sex and without a medical history of connect

SUBMITTER: Padjas A 

PROVIDER: S-EPMC12639174 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature