Comparison between SBMA and MPC coatings on PEEK surface: stability over time and anti-inflammatory effects in vitro.

ABSTRACT: The foreign body reaction often hinders the success of implantable devices, leading to fibrotic encapsulation. Controlling the post-implantation inflammatory phase is key to mitigating the foreign body reaction and promoting device integration. This paper compares three coating strategies for including anti-inflammatory agents onto polyether-ether-ketone (PEEK) surfaces, applying two different zwitterions, namely the 2-methacryloyloxyethyl phosphorylcholine (MPC) and [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBMA). Two different PEEK surface types were also compared, namely "rough surface" and "smooth surface" (average roughness: 7 μm ± 4 μm and 1.4 μm ± 0.3 μm, respectively). Focused ion beam-scanning electron microscopy (FIB-SEM) confirmed qualitatively the pr

SUBMITTER: Roventini E 

PROVIDER: S-EPMC12639175 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature