Cholecystectomy and the risk of osteoporosis and fractures: a systematic review and meta-analysis.

ABSTRACT:

Background

Cholecystectomy is a common surgical procedure for gallbladder diseases. Removal of the gallbladder alters bile flow and may affect the absorption of fat-soluble vitamins, especially vitamin D, which could influence bone metabolism. However, epidemiological studies have yielded inconsistent findings regarding its association with osteoporosis and fractures.

Objectives

To systematically evaluate the association between cholecystectomy and the risks of osteoporosis and fractures, and to examine potential effect modification by age.

Design

Systematic review and meta-analysis of cohort studies.

Methods

Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, cohort studies published up to June 1, 2025, were identified

SUBMITTER: Sun G 

PROVIDER: S-EPMC12639220 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature