Gut microbiota and metabolic signatures of anxiety in ulcerative colitis: a cross-sectional study.

ABSTRACT:

Background

Patients with ulcerative colitis (UC) usually experience anxiety symptoms that seriously affect their quality of life, treatment, and prognosis. Dysbiosis of the gut microbiota plays an important role in UC and mental illness. However, little is known about the role of the gut microbiota in UC patients with anxiety.

Objectives

To identify the gut-microbiome and fecal metabolome profiles uniquely associated with comorbid anxiety in UC patients and to explore potential biomarkers for diagnosis.

Design

A cross-sectional, two-group comparative study.

Methods

To study the underlying association between them, we recruited 126 UC patients in this study, including 78 with anxiety and 48 without anxiety. A total of 102 fecal samples were collected for metagen

SUBMITTER: Ping Y 

PROVIDER: S-EPMC12639231 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature