Translation element EIF4A1 is a potential divergent immune biomarker between colon cancer and rectal cancer.

ABSTRACT:

Objective

Given the global high incidence of colorectal cancer (CRC) and the need for subtype-specific molecular targets, this study aims to investigate the role and therapeutic potential of EIF4A1 in colon and rectal cancers.

Introduction

The potential of Eukaryotic translation initiation factor 4A1(EIF4A1) to guide prognosis and inform immunotherapeutic strategies in colon and rectal cancers warrants further investigation.

Methods

EIF4A1 expression levels were measured by quantitative real-time PCR (qRT-PCR), and EIF4A1 protein expression was evaluated via immunohistochemistry (IHC). Additionally, multi-dimensional database analyses were performed to characterize the biological functions of EIF4A1 and explore its heterogeneity in CRC.

Results

EIF4A1 expressio

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC12639241 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature