Intense light mitigates hypoxia-induced right ventricular remodeling and dysfunction through reducing inflammation associated with PF4⁺ resident macrophages.

ABSTRACT: Hypoxia-induced right ventricular (RV) remodeling and dysfunction present a significant health risk to populations experiencing prolonged hypoxic conditions. Intense light, a noninvasive and easily implemented intervention, has previously been reported to exert cardioprotective effects by improving myocardial ischemia. However, whether intense light provides protective benefits against RV remodeling and the underlying mechanisms remain largely unexplored. In this study, we established mouse models exhibiting RV remodeling and dysfunction through long-term hypoxia to investigate the protective effects of intense light. Echocardiography, hemodynamic parameters measurements, and Fulton index assessments were employed to evaluate RV dysfunction and remodeling. Additionally, single-nuclei RNA s

SUBMITTER: Tian D 

PROVIDER: S-EPMC12639265 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature