Risk Factors Associated With Incidence of Lung Cancer in Never-Smokers: A Systematic Review and Meta-Analysis.

ABSTRACT:

Objectives

Lung cancer is the leading cause of cancer mortality globally. Although often associated with smoking, up to 25% of cases worldwide and 50% in East Asia occur in "never-smokers." There are currently no robust tools for predicting lung cancer in individuals who have never smoked (LCINS) for populations outside East Asia.Together with a group of patient representatives, the authors of this study aimed to summarise risk factors for LCINS and quantify risk in different geographical regions.

Methods

This study was prospectively registered (PROSPERO-CRD42022379253). The systematic review and meta-analysis included studies published from 2017 and aimed to comprehensively investigate risk factors associated with LCINS incidence. Risk of bias was assessed using Newcastle-O

SUBMITTER: Naidu SB 

PROVIDER: S-EPMC12639266 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature