The relationship between glymphatic system, multi-level stress response, and psychological resilience.

ABSTRACT:

Background

Stress promotes affective, neural, endocrine, and immune responses. The glymphatic system, essential for waste clearance and immune homeostasis, protects the brain against adverse neurobiological changes. However, it remains unclear how the glymphatic system changes during acute stress, coordinates with multi-level stress responses, and relates to psychological resilience in humans.

Methods

We recruited 84 healthy middle-aged adults (mean age 29.26 ± 2.91, 50 males) without major physical, neurological, or psychological conditions. Glymphatic system function was assessed via the coupling between global blood-oxygen-level-dependent and cerebrospinal fluid signals (gBOLD-CSF coupling) before, immediately after, and 60 min after the Montreal Imaging Stress Task. Mood

SUBMITTER: Jin RR 

PROVIDER: S-EPMC12639269 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature