Telomere length, aging, and cognitive function in the Midwestern Amish.

ABSTRACT: Telomere length (TL) is a key indicator of biological aging. Understanding the association between TL and cognitive impairment may provide important insights into disease mechanisms for age-related neurodegenerative disorders, such as Alzheimer's disease (AD). However, the relationship between TL and cognitive function remains controversial, with studies reporting positive, negative, or no associations between them. This inconsistency may be attributed to genetic and environmental variations or differences in TL measurement methods. We conducted a comprehensive characterization of DNA sequence-determined TL and analyzed its association with cognitive function in the Midwestern Amish. The Midwestern Amish are a founder population demonstrating reduced genetic and environmental variation com

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12639303 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature