Systematic Review of Immune and Symptomatic Treatments for Stiff-Person Syndrome.

ABSTRACT:

Background and purpose

This systematic review evaluated the effectiveness and safety of immune and symptomatic treatments in patients with stiff-person syndrome (SPS).

Methods

A systematic search of PubMed, Embase, and the Cochrane Library was conducted up to September 30, 2024 in accordance with the PRISMA guidelines. All studies that involve SPS patients treated with symptomatic pharmacotherapy or immunotherapy and where the outcome is reported were included in the initial screening. Case reports were excluded. Two independent reviewers carried out study selection, bias assessment with the Murad et al. tool for case series, ROBINS-I for observational studies or RoB-2 for randomised trials, and data extraction into a predefined template. All available efficacy and safety da

SUBMITTER: Lenglet T 

PROVIDER: S-EPMC12639332 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature