Evaluation of genes and molecular pathways involved in ferroptosis in breast cancer: A systems biology and bioinformatics approach.

ABSTRACT:

Background

Breast cancer (BC) is a leading cause of cancer mortality worldwide. Ferroptosis, an unique form of iron-dependent cell death, has emerged as a promising therapeutic target to overcome drug resistance. This study aimed to identify key ferroptosis-related genes and their regulatory pathways that are dysregulated in BC.

Methods

Through a systems biology approach, we analyzed gene expression data from two independent GEO datasets. We identified differentially expressed genes (DEGs) in tumor versus normal tissues and intersected them with a curated database of ferroptosis regulators to define a high-confidence list of Ferroptosis-related DEGs (FeffDEGs). Subsequently, we performed functional enrichment, protein-protein interaction (PPI) network analysis to identify hu

SUBMITTER: Heydari A 

PROVIDER: S-EPMC12639381 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature