Ivermectin to reduce malaria transmission- safety and efficacy results from the BOHEMIA cluster randomized trial in Mozambique.

ABSTRACT:

Background

Endectocides are a novel vector control tool that reduce the survival and fertility of blood sucking arthropods that feed upon treated humans or animals. Ivermectin mass drug administration is under evaluation as a complementary strategy for malaria vector control. The BOHEMIA consortium conducted two cluster-randomized trials, one in Mozambique, reported here and one in Kenya, reported elsewhere.

Methods

The trial was conducted in Mopeia, a highly endemic district in Zambezia province, with perennial transmission and over 70% coverage of both indoor residual spraying and long-lasting insecticidal nets. As per protocol, we planned to randomise 53 clusters per arm (1:1:1), to receive either (a) single 400 mcg/kg dose of ivermectin to all eligible humans, once a mon

SUBMITTER: Chaccour C 

PROVIDER: S-EPMC12639382 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature