Establishment and characterization of preclinical models of human gynecologic tract carcinosarcomas demonstrates targetable FGFR1 alterations.

ABSTRACT:

Objective

Gynecologic carcinosarcoma is an uncommon but aggressive malignancy that frequently requires systemic therapy but therapeutic options are limited. Development of preclinical models is therefore important for therapeutic advancement.

Methods

Carcinosarcoma tumor (6 uterine and 1 tubo-ovarian) from 7 surgical samples were implanted into immunocompromised mice for patient-derived xenograft (PDX) and/or cell line development. The histologic, immunophenotypic and genetic features were characterized. Based on the observed molecular profiles and targetable molecular alterations, in vivo studies were conducted to evaluate the efficacy of targeted therapy on tumor growth.

Results

We established 1 cell line and 6 PDX models which recapitulated the dominant phenotype o

SUBMITTER: Wong NKY 

PROVIDER: S-EPMC12639385 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature