Key research priorities in methodological approaches for measuring the exposome and studying its role in the development of dementia.

ABSTRACT: There is growing recognition regarding the importance of the exposome, or the totality of exposures one experiences across the life course, in research on Alzheimer's disease and related dementias. However, the measurement of numerous exposures at once and over time, as well as modeling their effects on dementia risk, presents significant methodological challenges. Through community engagement and consensus-building processes integrating input from multidisciplinary panels of experts, we identified critical priority topics for methods used in studying links between the exposome and dementia risk, along with advances needed to address those priorities. We identified nine priority topics: high-dimensional and multimodal data, measurement error, harmonization across studies, mixtures of expos

SUBMITTER: Nichols E 

PROVIDER: S-EPMC12639404 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature