Putaminal hypermetabolism identifies Lewy body co-pathology in Alzheimer's disease.

ABSTRACT:

Introduction

The clinical implications of brain hypermetabolism remain unexplored in Lewy body disease (LBD) co-pathology in Alzheimer's disease (AD).

Methods

We investigated cognition, ¹⁸F-fluorodeoxyglucose positron emission tomography (PET), and cerebrospinal fluid tau phosphorylated at threonine 181 (pTau₁₈₁)/Aβ₄₂ plus α-synuclein seeding amplification assays (SAA) in controls, 217 SAA-negative AD (AD^SAA-), and 124 SAA-positive AD (AD^SAA+). Brain metabolism was assessed using subject residual profile (SRP) and standardized uptake value ratio (SUVR).

Results

Compared to AD^SAA-, AD^SAA+ showed putamen SRP hypermetabolism and middle occipital gyrus (MOG) SUVR hypometabolism. SAA positivity co

SUBMITTER: Kang S 

PROVIDER: S-EPMC12639405 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature