Fecal short-chain fatty acids vary by sex and amyloid status.

ABSTRACT:

Introduction

Short-chain fatty acids (SCFAs), produced by gut microbes, influence Alzheimer's disease (AD) pathology in animals. Less is known about SCFAs and AD in humans. We profiled feces of adults along the AD continuum to investigate gut microbiome and SCFA associations with AD pathology and cognition.

Methods

We measured SCFAs and bacterial abundances in fecal samples from 287 participants in the Wisconsin Alzheimer's Disease Research Center and Wisconsin Registry for Alzheimer's Prevention. We performed regressions examining associations between SCFAs or gut microbes and AD pathology and cognition.

Results

Fecal propionate, isovalerate, and propionate-producing bacteria are inversely associated with amyloid status. Mediation analysis found that propionate media

SUBMITTER: Kuehn JF 

PROVIDER: S-EPMC12639406 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature