Using metabolic syndrome severity in the "real world": Associations with diabetes and cardiovascular disease in all of us vs. NHANES.

ABSTRACT:

Background

While the severity of the metabolic syndrome (MetS) is associated with type 2 diabetes and cardiovascular disease (CVD) in research cohorts, it is unclear if this association remains when using clinically-collected data, which is more subject to error and bias.

Methods

We used a previously-validated MetS-severity z-score (MetS-Z) to compare the degree of cardiometabolic derangement between clinically-collected data from the electronic health-record (EHR) in the All-of-Us cohort (N = 101,676) with research-collected data from NHANES 2017-2020 (n = 3470). We assessed (separately) the odds of current diabetes and CVD in each cohort based on MetS z-score, adjusted for sex, race/ethnicity, education and income.

Results

Mean MetS-Z-scores in All of Us (vs. NHANES

SUBMITTER: DeBoer MD 

PROVIDER: S-EPMC12639442 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature