Association of genotypes at single-nucleotide polymorphisms in <i>IL-28B, TGF-β1</i>, <i>TP53, MTHFR</i> and <i>GSTP1</i> gene and their combinations with ischemic stroke: A case-control study.

ABSTRACT:

Objective

Ischemic stroke is a complex pathological condition in which the brain is damaged due to blockage of blood vessel(s) supplying blood to the brain. This study investigates the genotype and allelic frequency at the single-nucleotide polymorphism (SNP) rs8099917 in IL-28B, rs1800470 and rs1800472 in TGF-β1, rs1042522 in TP53, rs180133 in MTHFR and rs1695 in GSTP1 gene and correlates them individually or in various combinations with the incidence of ischemic stroke.

Methods

A total of 156 clinically confirmed ischemic stroke patients and 156 age and sex matched controls were enrolled from Multan District in Pakistan during September 2024 till February 2025. Tetra-primer amplification refractory mutation system-polymerase chain

SUBMITTER: Shakoor S 

PROVIDER: S-EPMC12639443 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature