Efficacy of magnesium sulfate as an adjuvant to local anesthetics in supraclavicular brachial plexus block: a meta-analysis of randomized trials.

ABSTRACT:

Background

Magnesium Sulfate (MS) maintains physiological functions in the body. Studies suggest its safety in regional anesthesia, despite off-label perineural use. We conducted a systematic review and meta-analysis to evaluate MS efficacy as an adjuvant in supraclavicular brachial plexus block.

Methods

The study was registered in PROSPERO (CRD42025641627) on 01/21/2025. We searched PUBMED, Embase, Cochrane, clinicaltrials.gov and gray literature for eligible studies. We included RCTs that: enrolled adult patients; involved orthopedic surgery with supraclavicular block; compared LA alone versus LA with MS; and reported primary outcomes. Primary outcomes were duration of sensory and motor block, while secondary outcomes included onset of sensory and motor block, PONV and res

SUBMITTER: Saraiva WB 

PROVIDER: S-EPMC12639445 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature