Intra-arrest therapeutic hypothermia with combined helium-mixed gas and cold fluid infusion significantly augments brain cooling efficiency: An experimental study in pigs.

ABSTRACT:

Objective

This study aimed to develop a more efficient method for intra-arrest therapeutic hypothermia (IATH) and demonstrate its usefulness in cardiopulmonary cerebral resuscitation.

Methods and results

The following experiments were performed in pigs while measuring the brain temperature, introducing cardiac arrest, and performing cardiopulmonary resuscitation. In experiment 1, the use of helium gas mixtures in cardiac arrest intra-arrest lung cooling (IALC) increased brain cooling efficiency. When the IATH method was performed by adding cold fluid infusion to IALC, a decrease in brain temperature of approximately 0.8 °C within 10 min was observed. In experiment 2, cerebral microdialysis (CMD) during the IATH method of cardiopulmonary resuscitation showed a slight elevatio

SUBMITTER: Sakurai A 

PROVIDER: S-EPMC12639464 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature